Cellular toxicologist

Stevenage, England, United Kingdom

12/18/2024

Site Name: UK - Hertfordshire - Stevenage

Posted Date: Dec 11 2024

Accountable for providing laboratory technical support and utilizing specialist advanced cellular modelling techniques to generate data that helps elucidate mechanisms of toxicity, understand species differences, identify novel translational safety biomarkers, and inform project decisions. With a solid background in cell culture and advanced cellular models (such as Complex In Vitro Models, Micro Physiological Systems, and/or Organ on Chip models), the scientist will carry out both paper and laboratory-based studies to support predictive, mechanistic, and translational toxicological investigations across new drug modalities, including Oligos, ADCs, and T-Cell Engagers for projects in discovery and development. Additionally, the scientist will offer subject matter expertise in specific technical or scientific areas, such as particular organ toxicities and cell model techniques.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

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Key Responsibilities,

• Independently selects, designs and executes innovative investigative toxicology experiments or technical work programs to support Project Issues with minimal supervision; work includes study planning, experiment organization, sample preparation, data generation, processing analysis and reporting. Plans next steps based on interpretation of results.
• Contributes to establishment and maintenance of scientifically current, state-of-the-art laboratory environment.
• Initiates new research directions in cellular toxicology and leads development of new cellular assay formats/techniques (from tissues, primary cells, or cell culture systems) for the investigation of mechanisms and translation of organ and cellular toxicities and safety risks to the clinic, including routine mammalian cell screening assays (e.g., cell mutation).
• Provide high quality data, acceptable to appropriate principles of data integrity (DI), including quality control (QC) of study data.
• Be a Subject Matter Expert (SME) in your field, with extensive theoretical and technical understanding and provide expert advice to Project Teams, advisory Safety Panels, Target Safety Reviews and external partners etc as required.
• Where needed understand the disease target under investigation, and if applicable the therapeutic area, and the programme/project plan and potential safety issues of assigned projects / studies.
• Prepare detailed oral or written reports within agreed timelines.
  
  
  

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals,

• MSc or PhD or equivalent by experience in Cellular biology, Molecular biology, Toxicology and/or other related biological science
• Extensive knowledge of and proficiency in use of multiple advanced in vitro cell model techniques and how to interpret and contextualise data for the purpose of risk assessment, ideally within a Pharmaceutical or Research Institute setting. Subject matter expertise for a specific technical area, related to in vitro cellular models, or a particular organ toxicity (liver, kidney, bone marrow), etc.
• Proficiency in laboratory and in silico techniques to build and implement new human relevant cell models or other assays to fill strategic gaps and meet Project needs; ideally with a focus on large molecules (Oligos, ADCs, and T-Cell Engagers etc).
• Familiar with platform data and bioinformatics software and working with data analysts/bioinformaticians to leverage high content data approaches to support toxicological MOA and risk assessment.
• Excellent written and verbal communication and organisational skills, ideally with evidence of a relevant publication record.
• Ability to work routinely across boundaries as part of cross functional matrix teams internally (e.g., with Genetic Toxicology & Molecular safety and others in Pre-Clinical Science and Project Teams) and potentially externally (inc. authorship and presentation of scientific content).
  
  
  

Preferred Qualifications:

If you have the following characteristics, it would be a plus,

• Have experience of providing technical subject matter expertise to drug development Project Teams, Safety Project Specialists, and other stakeholders, including provision of integrated assessments of pre-clinical toxicity data to support commitment to Candidate Selection or First Time in Human
• Experience of the use of in silico modelling platform applications or languages (e.g. Matlab or coding in R) with the potential to support adverse outcome pathways and translation of non-clinical data to the clinical setting and across species to humans.
  
  
  

Closing Date for Applications – 2nd January 2025 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert. 

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

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