Executive Director, Translational Sciences

Stevenage, England, United Kingdom

12/16/2024

Site Name: UK - Hertfordshire - Stevenage, USA - Pennsylvania - Upper Providence

Posted Date: Nov 27 2024

Reporting to Vice President of Respiratory and Immunology Translational Unit (RITU), the Executive Director, Translational Sciences will be responsible for innovative disease area translational initiatives to inform therapy area and programme biomarker strategies that will increase the probability of success of preclinical to clinical transitions and allow for earlier and higher confidence project-related decisions. This will include generation of foundational data as well as disease biomarkers development and validation that allow timely deployment of tools/biomarkers that can support detection of Proof of Mechanism (PoM), signs of clinical efficacy, Proof of Concept (PoC), and pairing Mechanisms of Action (MoAs) with patient subtypes to predict rapid or complete responder populations in respiratory, immunology, or emerging specialities.

The successful candidate will work closely with the RITU leadership team and the overarching research unit leadership teams, GSK matrix and external partners and will represent RITU at governance level. The individual will spearhead initiatives to increase portfolio value through the application of cutting-edge single cell technologies, techniques and analytics aligned to complex in vitro models, tissue biopsies and organ models, to develop deeper disease knowledge to inform target pathways and candidate molecule packages/rationales rooted in human disease pathological relevance.

Key Responsibilities:

• Translational Leadership:
• Provide strategic leadership contributing to deep understanding of Disease areas enabling the development and execution of translational research disease strategies to support the discovery and development of novel differentiated therapeutics including evaluation and diligence of business development opportunities.
• Translational innovation:
• Evaluate novel techniques and technologies (i.e. spatial transcriptomics) to inform translational initiatives, biomarker development and validation working in collaboration with platform teams and within a multi-functional matrix environment.
• Identify and guide validation of human assays (cells, tissues and organs) to enhance human translation and predictive value through the application of resources such as the Human Cell Atlas, disease tissue multi-omics data and genetic resources (external or proprietary).
• Disease Biomarker Strategy Development:
• Partner with the Disease Teams, Research Technologies and Precision Medicine to identify, establish disease biomarkers for decision making throughout clinical development phases and aligned with the overall research and development goals. This will include the identification, prioritisation and validation of disease relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and differentiated response prediction.
• Cross-functional Collaboration:
• Collaborate closely with cross-functional teams including the Translational, Disease Teams, Human Genetics & Genomics, biology groups, platforms, HBSM, Precision Medicine, data-sciences, regulatory affairs, and business development and commercial to ensure seamless integration of translational research and biomarker strategies across the drug development lifecycle.
• External Partnerships:
• Establish and maintain strategic collaborations with academic institutions, contract research organizations (CROs), and other external partners to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
• Foster a network of external experts and key opinion leaders to stay at the forefront of translational science and biomarker advancements across the industry.
• Contribute to evaluation and diligence of business development opportunities.
• Matrix Leadership:
• Provide mentorship, guidance, and professional development opportunities to ensure a high-performing and motivated team.
• Manage disease and project level resources, budgets, and timelines to ensure the successful execution of projects and achievement of milestones and RITU objectives.
• Represent RITU at portfolio governance reviews providing critical input to pipeline and investment decision making.
  
  
  

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field)
• Extensive experience in translational science and biomarker development within the pharmaceutical or biotechnology industry.
• Recognised translational/biomarker expert in scientific community through publications and contributions to the field.
• Extensive Disease level understanding and knowledge in translation/biomarkers implementation.
• Broad knowledge in technologies and methods used in translational research.
• Proven track record of program decision making through implementing biomarker strategies and delivering translational science insights in support of drug progression through clinical transition milestones.
• Experience leading/managing external collaborations and evaluation of business development opportunities.
• Strong executive management skills, with the ability to prioritize and manage multiple projects to meet timelines while maintaining attention to detail and high-performance standards.
• Excellent inclusive matrix leadership skills, with the ability to create psychological safety, inspire and motivate a team towards achieving common goals.
• Ability to adapt to a fast-paced and evolving research environment, with strong problem-solving and critical-thinking skills.
  
  
  

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Awareness of bioinformatic / computational methods supporting integrated analysis and interpretation of translational and biomarker-related data sets.
• Knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation.
  
  
  

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive .

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.