Senior Scientist - Molecular Biology

Life Reimagined

Constructive Bio is a VC-backed biotechnology start-up based in Whittlesford, Cambridge. Our breakthrough technology harnesses the power of genome rewriting and genetic code reprogramming to make valuable products that positively impact the world. We will use our platform to turn cells into bio-renewable factories for the production of novel molecules that were previously inaccessible to natural biology, with diverse uses in industries spanning healthcare, biological research, materials and electronics.

Constructive Bio is a spinout from Professor Jason Chin's laboratory at the MRC Laboratory of Molecular Biology in Cambridge. Learn more about the Chin lab achievements here: https://www2.mrc-lmb.cam.ac.uk/ccsb/jason-chin/

We want to build a team with trust and respect for each other and create a culture of collaboration, openness, curiosity and scientific excellence.

We are built on three principles:

• We imagine: We think big and plan our own path for success.
• We pioneer: We take action and grow together as one to break moulds.
• We deliver: When take ownership and work together to deliver excellence.

Overview of the role

We are looking for a talented molecular biologist to join our team. As part of the Synthetic Genomics team, the post holder will work collaboratively with other scientists, engineers and bioinformaticians to further develop our proprietary technologies for genome synthesis and large DNA assembly, which will enable us to create designer organisms with programmable phenotypes. The ideal candidate will have a background in biological engineering and excellent problem-solving skills, as well as a proven track record for designing, executing and documenting experiments. As an early member of the team, you would have the opportunity to make a big impact in the development of our platform.

Responsibilities:

• Development and deployment of our proprietary technologies for large-scale genome engineering and rewriting.
• Independent design and execution of experiments for DNA manipulation and assembly, with an emphasis on prokaryotes.
• Collaborate closely with experimental and computational colleagues to deliver results on time and in alignment with the company’s objectives.
• Stay up to date with the latest developments in genome synthesis and the rewriting of large DNA.
• Record, analyze and interpret data, regularly communicate progress, results and challenges with the wider R&D team.

Requirements:

• A PhD degree plus significant experience in Molecular Biology, Microbiology, Biochemistry, Bioengineering or a related field
• Proficiency in the design and execution of DNA cloning, including Gibson, GoldenGate assembly or similar
• Experience analysing and interpreting next-generation sequencing data (particularly Illumina and/or Oxford Nanopore)
• Solid understanding of molecular biology techniques for DNA manipulation in prokaryotes, such as base editing, homologous recombination, conjugation, transduction or transposition
• Strong problem-solving skills and the ability to work independently in a fast-paced environment
• Excellent written and oral communication skills and ability to work collaboratively in a team

Desirable:

• Good working knowledge of bacterial genetics, tools for genome annotation and genomic databases
• Familiarity with laboratory automation equipment and high-throughput molecular biology workflows
• Line management or project management experience

What’s in it for you? Why work at Constructive Bio?

We are a small but rapidly growing team - as an early member, you will be immersed in different aspects of the early company set up and there will be ample opportunities for personal development. This is a unique chance to make a big impact in our platform and company culture. We have recently moved to our new modern offices located in Whittlesford, near Cambridge which offers on-site parking. In addition, we offer a competitive benefits package which includes Private Healthcare and a generous pension contribution.

Constructive Bio is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.