Senior Scientist – Peptide Chemistry

Cambridge, England, United Kingdom

1/2/2025

Job Title: Senior Scientist – Peptide Chemistry

Location: Cambridge

Salary: competitive

Introduction to role:

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases.

Currently we are seeking a skilled and enthusiastic peptide chemist, who will be part of a chemistry team developing the next generation of peptide medicines.

As a peptide chemist, you will be responsible for the design and chemical synthesis of therapeutic peptides and reagents. We are looking for someone who has a good understanding and background in solid-phase synthesis to support delivery of our peptide portfolio. In this laboratory-based position, you will be responsible for multi-step synthesis, purification and analytical characterisation of complex peptides. You will work independently within research teams and also with internal or external stakeholders. This role requires a strong background in peptide chemistry, excellent problem-solving skills and the ability to work in a fast-paced, collaborative environment.

As part of a growing team, you will benefit from numerous personal and professional development opportunities at AstraZeneca.

Accountabilities:

• Independently plan and execute complex experimental work
• Design and synthesize peptides using solid-phase peptide synthesis (SPPS) techniques, using both automated peptide synthesisers and manual procedures
• Troubleshoot and resolve synthetic and analytical challenges
• Cleavage of peptides from resin supports, purification by preparative HPLC and analysis using mass spectrometry techniques
• Contribute to multi-disciplinary research and drug development
• Communicate results to global project teams and stakeholders
• Maintain accurate and detailed experimental records and results
• Stay current with advancements in peptide chemistry and related fields
  
  
  

Essential Skills/Experience:

• Postgraduate qualification (or equivalent) in Chemistry, Biochemistry or relevant subject area
• Deep understanding of chemistry and peptide chemistry
• Technical proficiency in solid-phase and/or peptide synthesis via manual syntheses or automated peptide synthesisers
• Familiarity and working knowledge of HPLC purification and mass spectrometry
• Excellent record-keeping and strong written and verbal communication skills
• Experience of working within a team environment and developing good working relationships with individuals across organisational boundaries
  
  
  

Desirable Skills/Experience:

• PhD (or Master’s degree with equivalent lab-based experience)
• Skills in rational/ computational design of peptides
• Previous experience within the pharmaceutical industry
• Experience of working with peptide conjugates or bioconjugation techniques
  
  
  

What is next?

Are you ready to make a difference? Apply today and join us in our mission to improve global public health!

We welcome your applications not later than 12th January 2025.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Are you ready to make a difference? Apply today and join us in our mission to improve global public health!