Year in industry – Disease Biology (Oncology Research)
Company
Location
Oxford, England, United Kingdom
Posted At
12/11/2024
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Description
Location of role Oxford, UK
Department Oncology Research
Key Responsibilities We have an opportunity in our Research Group for a 12-month placement (Year in industry). We are looking for enthusiastic and highly motivated individuals who would relish the chance to learn from Immunocore’s cutting edge science and corporate growth.
Cancer is a leading cause of death worldwide. Approved Standard-of-Care (SoC) medicines (incl. chemotherapy, kinase inhibitors, immune checkpoint inhibitors) extend patient survival, although relapse and resistance are common. Deeper understanding of the biology that fuels tumorigenesis, and better ways of modelling disease, are essential to generate more efficacious medicines.
Patient derived organoids (PDOs) are ex vivo 3D models derived from adult stem cells (ASCs) that recapitulate aspects of tumour biology not always possible to reproduce in 2D cancer cell lines. The candidate would help expand our normal and cancer PDO disease modelling capabilities by leveraging in-house expertise and outputs from our external collaborations. Robust workflows will be implemented to derive/grow PDO models from ASCs. Models will be characterised using a range of techniques including microscopy and flow cytometry. The candidate will engineer PDOs to harbour cell states known to drive disease and implement advanced immune co-culture assays. The effect of SoC and ImmTAC redirected T-cell activation on normal and cancer PDO models will be explored to understand our ability to kill tumour cells whilst sparing normal cell subsets.
Key Responsibilities
Undertaking (currently in second year and looking for a year in industry) BSc. in Biological or Biomedical Sciences, Biochemistry, or Immunology.
What will you receive?
Join Immunocore for a paid placement and gain insights from our innovative science and corporate growth. You’ll enjoy 25 days of annual leave (pro rata), pension scheme eligibility, and access to our active Sports and Social Club with subsidized events.
Please note this is a full-time position is based at our Abingdon, Oxfordshire office and contracted through a third party.
Important information for all applicants
The application deadline is 10th January 2025, with phone interviews starting shortly after. Shortlisted candidates will be invited to an in-person Assessment Centre on 3rd, 4th, 5th, or 6th March 2025, providing an opportunity to meet current placement students, learn about the role, and socialize with employees.
Placements are expected to begin on 8th September 2025.
Please note - should you not be available on all the above dates, unfortunately, we won't be able to proceed with your application.
If interested, apply with your CV and a cover letter (combined in one document) stating your main areas of interest.
About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Department Oncology Research
Key Responsibilities We have an opportunity in our Research Group for a 12-month placement (Year in industry). We are looking for enthusiastic and highly motivated individuals who would relish the chance to learn from Immunocore’s cutting edge science and corporate growth.
Cancer is a leading cause of death worldwide. Approved Standard-of-Care (SoC) medicines (incl. chemotherapy, kinase inhibitors, immune checkpoint inhibitors) extend patient survival, although relapse and resistance are common. Deeper understanding of the biology that fuels tumorigenesis, and better ways of modelling disease, are essential to generate more efficacious medicines.
Patient derived organoids (PDOs) are ex vivo 3D models derived from adult stem cells (ASCs) that recapitulate aspects of tumour biology not always possible to reproduce in 2D cancer cell lines. The candidate would help expand our normal and cancer PDO disease modelling capabilities by leveraging in-house expertise and outputs from our external collaborations. Robust workflows will be implemented to derive/grow PDO models from ASCs. Models will be characterised using a range of techniques including microscopy and flow cytometry. The candidate will engineer PDOs to harbour cell states known to drive disease and implement advanced immune co-culture assays. The effect of SoC and ImmTAC redirected T-cell activation on normal and cancer PDO models will be explored to understand our ability to kill tumour cells whilst sparing normal cell subsets.
Key Responsibilities
- Characterize PDO morphology, viability, and growth conditions.
- Phenotype PDOs using advanced imaging techniques and flow cytometry.
- Contribute to external collaborations, assess reproducibility, and implement learnings to generate PoC data in-house.
- Assess and establish co-culture systems
- Assess the effect of ImmTAC and SoC molecules on tumour killing and cell populations within the PDOs.
Undertaking (currently in second year and looking for a year in industry) BSc. in Biological or Biomedical Sciences, Biochemistry, or Immunology.
What will you receive?
Join Immunocore for a paid placement and gain insights from our innovative science and corporate growth. You’ll enjoy 25 days of annual leave (pro rata), pension scheme eligibility, and access to our active Sports and Social Club with subsidized events.
Please note this is a full-time position is based at our Abingdon, Oxfordshire office and contracted through a third party.
Important information for all applicants
The application deadline is 10th January 2025, with phone interviews starting shortly after. Shortlisted candidates will be invited to an in-person Assessment Centre on 3rd, 4th, 5th, or 6th March 2025, providing an opportunity to meet current placement students, learn about the role, and socialize with employees.
Placements are expected to begin on 8th September 2025.
Please note - should you not be available on all the above dates, unfortunately, we won't be able to proceed with your application.
If interested, apply with your CV and a cover letter (combined in one document) stating your main areas of interest.
About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Advertise with us.
Please contact: hello@huntukvisasponsors.com
Please contact: hello@huntukvisasponsors.com
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